Clinico-Neuropathological Findings in the Oldest Old from the Georgia Centenarian Study.

ABSTRACT:

Background

Centenarian studies are important sources for understanding of factors that contribute to longevity and healthy aging. Clinico-neuropathological finding is a key in identifying pathology and factors contributing to age-related cognitive decline and dementia in the oldest old.

Objective

To characterize the cross-sectional relationship between neuropathologies and measures of premortem cognitive performance in centenarians.

Methods

Data were acquired from 49 centenarians (≥98 years) from the Georgia Centenarian Study. Cognitive assessment from the time point closest to mortality was used (<1 year for all subjects) and scores for cognitive domains were established. Neuropathologies [cerebral atrophy, ventricular dilation, atherosclerosis, cerebral amyloid angi

SUBMITTER: Tanprasertsuk J 

PROVIDER: S-EPMC7309277 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature