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Scalable Synthesis of Esp and Rhodium(II) Carboxylates from Acetylacetone and RhCl3·xH2O.

ABSTRACT: Rhodium(II) carboxylates are privileged catalysts for the most challenging carbene-, nitrene-, and oxo-transfer reactions. In this work, we address the strategic challenges of current organic and inorganic synthesis methods to access these rhodium(II) complexes through an oxidative rearrangement strategy and a reductive ligation reaction. These studies illustrate the multiple benefits of oxidative rearrangement in the process-scale synthesis of congested carboxylates over nitrile anion alkylation reactions, and the impressive effect of inorganic additives in the reductive ligation of rhodium(III) salts.

SUBMITTER: Martinez-Castro E 

PROVIDER: S-EPMC7309316 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Scalable Synthesis of Esp and Rhodium(II) Carboxylates from Acetylacetone and RhCl<sub>3</sub>·<i>x</i>H<sub>2</sub>O.

Martínez-Castro Elisa E   Suárez-Pantiga Samuel S   Mendoza Abraham A  

Organic process research & development 20200414 6

Rhodium(II) carboxylates are privileged catalysts for the most challenging carbene-, nitrene-, and oxo-transfer reactions. In this work, we address the strategic challenges of current organic and inorganic synthesis methods to access these rhodium(II) complexes through an oxidative rearrangement strategy and a reductive ligation reaction. These studies illustrate the multiple benefits of oxidative rearrangement in the process-scale synthesis of congested carboxylates over nitrile anion alkylatio  ...[more]