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GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches.

ABSTRACT: Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed. Granulocyte-macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung inflammation and immunological disease. Both administration and inhibition of GM-CSF are currently being therapeutically tested in COVID-19 clinical trials. This Perspective discusses the pleiotropic biology of GM-CSF and the scientific merits behind these contrasting approaches.

SUBMITTER: Lang FM 

PROVIDER: S-EPMC7309428 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches.

Lang Frederick M FM   Lee Kevin M-C KM   Teijaro John R JR   Becher Burkhard B   Hamilton John A JA  

Nature reviews. Immunology 20200623 8

Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed. Granulocyte-macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung inflammation and immunological disease. Both administration and inhibition of GM-CSF are currently being therapeutically tested in COVID-19 clinical trials. This Perspective discusses the pleiotropic biology of GM-CSF and the scientific mer  ...[more]

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