Boosting of the enhanced permeability and retention effect with nanocapsules improves the therapeutic effects of cetuximab.

ABSTRACT: Objective: The introduction of therapeutic antibodies (tAbs) into clinical practice has revolutionized tumor treatment strategies, but their tumor therapy efficiency is still far below expectations because of the rapid degradation and limited tumor accumulation of tAbs. Methods: We developed a nanocapsule-based delivery system to induce the self-augmentation of the enhanced permeability and retention (EPR) effect. This system constantly penetrated across the blood-tumor barrier into the tumor while avoiding the attack of tAbs by the immune system. The biodistribution and therapeutic effect were tested with single dose administration of nanocapsule-tAbs in vivo. Results: The accumulation of Nano(cetuximab) within subcutaneous PC9 tumors was gradually enhanced ove

SUBMITTER: Yang C 

PROVIDER: S-EPMC7309461 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature