Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults.

ABSTRACT:

Importance

Quadruple misfolded proteins (tau neurofibrillary tangles, amyloid-β [Aβ], α-synuclein, and transactive response DNA-binding protein 43 [TDP-43]) in the same brain are relatively common in aging. However, the clinical presentation, associated factors, frequency in community-based cohorts, genetic characteristics, and cognitive trajectories associated with the quadruple misfolded proteins phenotype are not well understood.

Objective

To describe the quadruple misfolded proteins phenotype, including the trajectories of global cognition, in an autopsy cohort.

Design, setting, and participants

This retrospective cohort study used brain autopsy data from the University of Kentucky Alzheimer Disease Center (UK-ADC) Brain Bank. Participants were deceased individual

SUBMITTER: Karanth S 

PROVIDER: S-EPMC7309572 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature