Substantial Cardiovascular Morbidity in Adults With Lower-Complexity Congenital Heart Disease.

ABSTRACT:

Background

Although lower-complexity cardiac malformations constitute the majority of adult congenital heart disease (ACHD), the long-term risks of adverse cardiovascular events and relationship with conventional risk factors in this population are poorly understood. We aimed to quantify the risk of adverse cardiovascular events associated with lower-complexity ACHD that is unmeasured by conventional risk factors.

Methods

A multitiered classification algorithm was used to select individuals with lower-complexity ACHD and individuals without ACHD for comparison among >500 000 British adults in the UK Biobank. ACHD diagnoses were subclassified as isolated aortic valve and noncomplex defects. Time-to-event analyses were conducted for the primary end points of fatal or nonfatal

SUBMITTER: Saha P 

PROVIDER: S-EPMC7309588 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature