Histidine Utilization Is a Critical Determinant of Acinetobacter Pathogenesis.

ABSTRACT: Acinetobacter baumannii is a nosocomial pathogen capable of causing a range of diseases, including respiratory and urinary tract infections and bacteremia. Treatment options are limited due to the increasing rates of antibiotic resistance, underscoring the importance of identifying new targets for antimicrobial development. During infection, A. baumannii must acquire nutrients for replication and survival. These nutrients include carbon- and nitrogen-rich molecules that are needed for bacterial growth. One possible nutrient source within the host is amino acids, which can be utilized for protein synthesis or energy generation. Of these, the amino acid histidine is among the most energetically expensive for bacteria to synthesize; therefore, scavenging histidine from the environment is like

SUBMITTER: Lonergan ZR 

PROVIDER: S-EPMC7309604 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature