Opsonophagocytosis of Chlamydia pneumoniae by Human Monocytes and Neutrophils.

ABSTRACT: The human respiratory tract pathogen Chlamydia pneumoniae, which causes mild to severe infections, has been associated with the development of chronic inflammatory diseases. To understand the biology of C. pneumoniae infections, several studies have investigated the interaction between C. pneumoniae and professional phagocytes. However, these studies have been conducted under nonopsonizing conditions, making the role of opsonization in C. pneumoniae infections elusive. Thus, we analyzed complement and antibody opsonization of C. pneumoniae and evaluated how opsonization affects chlamydial infectivity and phagocytosis in human monocytes and neutrophils. We demonstrated that IgG antibodies and activation products of complement C3 and C4 are deposited on the surface of C. pneumoniae elementar

SUBMITTER: Lausen M 

PROVIDER: S-EPMC7309617 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature