An Integrated Approach Identifies Mediators of Local Recurrence in Head and Neck Squamous Carcinoma.

ABSTRACT: Purpose: Head and neck squamous cell carcinomas (HNSCCs) cause more than 300,000 deaths worldwide each year. Locoregional and distant recurrences represent worse prognostic events and accepted surrogate markers of patients' overall survival. No valid biomarker and salvage therapy exist to identify and treat patients at high-risk of recurrence. We aimed to verify if selected miRNAs could be used as biomarkers of recurrence in HNSCC.Experimental Design: A NanoString array was used to identify miRNAs associated with locoregional recurrence in 44 patients with HNSCC. Bioinformatic approaches validated the signature and identified potential miRNA targets. Validation experiments were performed using an independent cohort of primary HNSCC samples and a panel of HNSCC cell lines.

SUBMITTER: Citron F 

PROVIDER: S-EPMC7309652 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature