Kratom and Pain Tolerance: A Randomized, Placebo-Controlled, Double-Blind Study.

ABSTRACT: Background: Kratom has a long history of traditional medicine use in Southeast Asia. Consumption of kratom products has also been reported in the US and other regions of the world. Pain relief is among many self-reported kratom effects but have not been evaluated in controlled human subject research. Methods: Kratom effects on pain tolerance were assessed in a randomized, placebo-controlled, double-blind study. During a 1-day inpatient stay, participants received a randomized sequence of kratom and placebo decoctions matched for taste and appearance. Pain tolerance was measured objectively in a cold pressor task (CPT) as time (seconds) between the pain onset and the hand withdrawal from the ice bath. Health status, vital signs, objective, and subjective indicators of withdraw

SUBMITTER: Vicknasingam B 

PROVIDER: S-EPMC7309661 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature