Association of LIN28B polymorphisms with chronic hepatitis B virus infection.

ABSTRACT:

Background

LIN28B is involved in multiple cellular developmental processes, tissue inflammatory response and tumourigenesis. The association of LIN28B polymorphisms with hepatitis B virus (HBV) infection remains unknown.

Methods

This study investigated the association of LIN28B rs314277, rs314280, rs369065 and rs7759938 polymorphisms in patients with chronic HBV infection, a major cause of liver disease including hepatocellular carcinoma (HCC). A total of 781 individuals including 515 cases of chronic HBV infection (91 asymptomatic carrier status, 128 chronic hepatitis, 127 cirrhosis and 169 HCC), 97 HBV infection resolvers and 169 healthy controls were investigated.

Results

LIN28 rs314280 genotypes GA + AA were higher in resolver and controls than patients (P = 0.011

SUBMITTER: Han Q 

PROVIDER: S-EPMC7310063 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature