Familial aggregation and heritability of ankylosing spondylitis - a Swedish nested case-control study.

ABSTRACT: OBJECTIVES:AS is known to be a highly heritable disease, but previous studies on the magnitude of the familial aggregation and heritability of AS have been small and inconclusive, with familial relative risks ranging from 17 to 94. We aimed to improve estimates of these factors by studying families of all subjects diagnosed with AS in Sweden over a period of 16 years and to investigate if familial risks vary by sex or type of relative. METHODS:In a nested case-control study, we identified AS index patients from the National Patient Register (NPR) and the Swedish Rheumatology Quality Register (SRQ) between 2001 and 2016. Each index patient was matched on age and sex to up to 50 general population controls. First-degree relatives of index patients and controls were identified through the Mul

SUBMITTER: Morin M 

PROVIDER: S-EPMC7310084 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature