Early response to anti-TNF predicts long-term outcomes including sustained remission: an analysis of the BSRBR-RA.

ABSTRACT: OBJECTIVE:To identify different trajectories of disease activity in patients with RA following initiation of a first anti-TNF. METHODS:Patients with RA starting their first anti-TNF between 2001 and 2013 were selected from the British Society for Rheumatology Biologics Register for RA. Six-monthly DAS28-ESR scores were used to identify trajectories of disease activity using latent class modelling. Data were included for six follow-ups after registration (approximately 3 years). Subgroup analysis examined changes in disease activity profiles over time. RESULTS:A total of 14 436 patients with RA starting their first anti-TNF were enrolled between 2001 and 2013 (13 115 between 2001 and 2008, 1321 between 2010 and 2013). The mean number of DAS28-ESR scores was 3.5/patient (s.d. 2.1), with a me

SUBMITTER: Hamann PDH 

PROVIDER: S-EPMC7310091 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature