Synovitis in rheumatoid arthritis detected by grey scale ultrasound predicts the development of erosions over the next three years.

ABSTRACT: OBJECTIVES:To evaluate grey scale US (GSUS) and power Doppler US synovitis (PDUS), separately or in combination (CombUS), to predict joint damage progression in RA. METHODS:In this cohort study nested in the Swiss RA register, all patients with sequential hand radiographs at their first US assessment were included. We analysed the summations of semi-quantitative GSUS, PDUS and CombUS assessments of both wrists and 16 finger joints (maximum 54 points) at their upper limit of normal, their 50th, 75th or 87.5th percentiles for the progression of joint damage (ΔXray). We adjusted for clinical disease activity measures at baseline, the use of biological DMARDs and other confounders. RESULTS:After a median of 35 months, 69 of 250 patients with CombUS (28%), 73 of 259 patients with PDUS (28%) and

SUBMITTER: Moller B 

PROVIDER: S-EPMC7310093 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature