Repair of osteochondral defect using icariin-conditioned serum combined with chitosan in rabbit knees.

ABSTRACT:

Background

Osteochondral defects caused by an acute traumatic injury or articular degeneration remains difficult to be manipulated. Repair of articular defects is still a great challenge for both tissue engineers and orthopedic surgeons. Therefore, combination of biomaterials with cartilage promotive drugs is well worth being developed to support the regeneration of both cartilage and subchondral bone.

Methods

Rabbits undergoing osteochondral defect surgery were intrarticularly injected with icariin-conditioned serum (ICS), chitosan (CSSH) and combination of ICS with CSSH, respectively. Gait analysis was performed using VICON motion capture system. ICRS score and immunohistochemical (IHC) analysis including H&E, Safranin O, toluidine blue and collagen II staining was employe

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7310103 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature