Modeling the Tumor Microenvironment and Pathogenic Signaling in Bone Sarcoma.

ABSTRACT: Investigations of cancer biology and screening of potential therapeutics for efficacy and safety begin in the preclinical laboratory setting. A staple of most basic research in cancer involves the use of tissue culture plates, on which immortalized cell lines are grown in monolayers. However, this practice has been in use for over six decades and does not account for vital elements of the tumor microenvironment that are thought to aid in initiation, propagation, and ultimately, metastasis of cancer. Furthermore, information gleaned from these techniques does not always translate to animal models or, more crucially, clinical trials in cancer patients. Osteosarcoma (OS) and Ewing sarcoma (ES) are the most common primary tumors of bone, but outcomes for patients with metastatic or recurrent d

SUBMITTER: Molina ER 

PROVIDER: S-EPMC7310212 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature