The local hypothalamic-pituitary-adrenal axis in cultured human dermal papilla cells.

ABSTRACT:

Background

Stress is an important cause of skin disease, including hair loss. The hormonal response to stress is due to the HPA axis, which comprises hormones such as corticotropin releasing factor (CRF), adrenocorticotropic hormone (ACTH), and cortisol. Many reports have shown that CRF, a crucial stress hormone, inhibits hair growth and induces hair loss. However, the underlying mechanisms are still unclear. The aim of this study was to examine the effect of CRF on human dermal papilla cells (DPCs) as well as hair follicles and to investigate whether the HPA axis was established in cultured human DPCs.

Results

CRF inhibited hair shaft elongation and induced early catagen transition in human hair follicles. Hair follicle cells, both human DPCs and human ORSCs, expressed CRF

SUBMITTER: Lee EY 

PROVIDER: S-EPMC7310274 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature