In-depth immune cellular profiling reveals sex-specific associations with frailty.

ABSTRACT:

Background

With advancing age, the composition of leukocyte subpopulations in peripheral blood is known to change, but how this change differs between men and women and how it relates to frailty is poorly understood. Our aim in this exploratory study was to investigate whether frailty is associated with changes in immune cell subpopulations and whether this differs between men and women. Therefore, we performed in-depth immune cellular profiling by enumerating a total of 37 subpopulations of T cells, B cells, NK cells, monocytes, and neutrophils in peripheral blood of 289 elderly people between 60-87 years of age. Associations between frailty and each immune cell subpopulation were tested separately in men and women and were adjusted for age and CMV serostatus. In addition, a rando

SUBMITTER: Samson LD 

PROVIDER: S-EPMC7310472 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature