Characterization of mucosa-associated Escherichia coli strains isolated from Crohn's disease patients in Brazil.

ABSTRACT:

Background

Crohn's disease (CD) is characterized by chronic inflammation of the human intestine. Several studies have demonstrated that the intestinal mucosa of CD patients in Western countries is abnormally colonized by adherent-invasive Escherichia coli (AIEC) strains. However, no studies to date have focused on the involvement of such E. coli strains in CD patients in Brazil. Here, we characterized E. coli strains associated with the ileal mucosa of Brazilian CD patients (ileal biopsies from 35 subjects, 24 CD patients and 11 controls).

Results

The colonization level of adherent Enterobacteriaceae associated with the ileal mucosa of CD patients was significantly higher than that of the controls. The proportions of E. coli strains belonging to phylogroups B1 and B2 were tw

SUBMITTER: Costa RFA 

PROVIDER: S-EPMC7310525 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature