Evolution and transition of expression trajectory during human brain development.

ABSTRACT:

Background

The remarkable abilities of the human brain are distinctive features that set us apart from other animals. However, our understanding of how the brain has changed in the human lineage remains incomplete, but is essential for understanding cognition, behavior, and brain disorders in humans. Here, we compared the expression trajectory in brain development between humans and rhesus macaques (Macaca mulatta) to explore their divergent transcriptome profiles.

Results

Results showed that brain development could be divided into two stages, with a demarcation date in a range between 25 and 26 postconception weeks (PCW) for humans and 17-23PCWfor rhesus macaques, rather than birth time that have been widely used as a uniform demarcation time of neurodevelopment across spec

SUBMITTER: Li ML 

PROVIDER: S-EPMC7310562 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature