Assessing Residual Bias in Estimating Influenza Vaccine Effectiveness: Comparison of High-dose Versus Standard-dose Vaccines.

ABSTRACT:

Background

Estimating influenza vaccine effectiveness using an unvaccinated comparison group may result in biased effect estimates.

Objectives

To explore the reduction of confounding bias in an active comparison of high-dose versus standard-dose influenza vaccines, as compared with vaccinated versus unvaccinated comparisons.

Methods

Using Medicare data from the United States end-stage renal disease program (2009-2013), we compared the risk of all-cause mortality among recipients of high-dose vaccine (HDV) versus standard-dose vaccine (SDV), HDV versus no vaccine, and SDV versus no vaccine. To quantify confounding bias, analyses were restricted to the preinfluenza season, when the protective effect of vaccination should not yet be observed. We estimated the standardize

SUBMITTER: Butler AM 

PROVIDER: S-EPMC7310582 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature