CD4⁺ T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion.

ABSTRACT:

Background

Aging is the most important risk factor for prostate cancer (PCa), but how age contributes to PCa is poorly understood. Aging is characterized by low-grade systemic inflammation (i.e., inflammaging) that is often attributed to the progressive activation of immune cells over time, which may play an important role in prostate carcinogenesis. Th17 response is elevated in aging humans and mice, but it remains unknown whether it is increased in prostate tissue or contributes to prostate carcinogenesis during aging. In this study, we aimed to determine the role of age-related Th17 response in PCa cell growth, migration, and invasion.

Methods

C57BL/6J (B6) mouse was used as an aging animal model and the prostate histopathology during aging was analyzed. Splenic CD4⁺

SUBMITTER: Liu S 

PROVIDER: S-EPMC7310589 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature