Urate-lowering therapy may mitigate the risks of hospitalized stroke and mortality in patients with gout.

ABSTRACT:

Objectives

Although studies have demonstrated the association of hyperuricemia with cardiovascular (CV) diseases, few have explored the effect of urate-lowering therapy (ULT) on the incidence of CV diseases. Therefore, we compared the risks of hospitalized coronary artery disease (CAD), stroke, heart failure (HF), and all-cause mortality between ULT users and nonusers among patients with gout.

Methods

We performed this retrospective cohort study using Taiwan's population-based National Health Insurance Research Database. In total, 5218 patients with gout were included from 2000 to 2012. We compared the incidence rates (IRs) of hospitalized CAD, stroke, HF, and all-cause mortality between ULT users and matched nonusers.

Results

The IRs of hospitalized stroke were 0.6 a

SUBMITTER: Yen FS 

PROVIDER: S-EPMC7310696 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature