Integrated analysis identifies an immune-based prognostic signature for the mesenchymal identity in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) has been divided into 4 consensus molecular subtypes (CMSs), of which CMS4 has the mesenchymal identity and the highest relapse rate. Our goal is to develop a prognostic signature by integrating the immune system and mesenchymal modalities involved in CMS4.

Methods

The gene expression profiles collected from 5 public datasets were applied to this study, including 1280 samples totally. Network analysis was applied to integrate the mesenchymal modalities and immune signature to establish an immune-based prognostic signature for CRC (IPSCRC).

Results

We identified 6 immune genes as key factors of CMS4 and established the IPSCRC. The IPSCRC could significantly divide patients into high- and low- risk groups in terms of relapse-free survi

SUBMITTER: Zhang B 

PROVIDER: S-EPMC7310905 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature