Phase I randomized single-blinded controlled study investigating the potential benefit of aerobic exercise in degenerative cerebellar disease.

ABSTRACT:

Objectives

To investigate whether people with cerebellar degeneration can perform rigorous aerobic exercise and to assess the clinical impact of training.

Design

Randomized single-blinded controlled, feasibility study comparing aerobic training to no training.

Setting

Home intervention, assessments conducted at an academic medical center.

Subjects

Twenty individuals with cerebellar degeneration caused by a range of genetic disorders.

Intervention

Aerobic training consisted of four weeks of stationary bicycle training, five times per week for 30-minute sessions. Intensity ranged from 65% to 80% of the participant's maximal heart rate determined during cardiopulmonary exercise testing.

Main measures

Primary outcome measure was change in the Scale fo

SUBMITTER: Barbuto S 

PROVIDER: S-EPMC7311185 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature