Association between the MUC1 rs4072037 Polymorphism and Risk of Gastric Cancer and Clinical Outcomes.

ABSTRACT:

Purpose

Mucin 1 (MUC1) was identified as a gastric cancer (GC) susceptibility gene by genome-wide association studies in Asians and candidate gene studies in Europeans. This study aimed to investigate the association between the MUC1 rs4072037 polymorphism and GC in terms of the Lauren classification and long-term clinical outcomes.

Materials and methods

A total of 803 patients with GC and 816 unrelated healthy controls were enrolled in the study. The association between the MUC1 rs4072037 variant and GC histological types and clinical outcomes, including tumor recurrence and prognosis was investigated.

Results

The major A allele of rs4072037 was associated with increased GC risk (P<0.05). In subtype analysis, the association was most signi

SUBMITTER: Kim BS 

PROVIDER: S-EPMC7311214 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature