Induced Tumor Heterogeneity Reveals Factors Informing Radiation and Immunotherapy Combinations.

ABSTRACT:

Purpose

To investigate how induced tumor heterogeneity influences immune responses to radiotherapy with different proportions of mixed immune-responsive and unresponsive tumor cells in a triple-negative breast cancer model. It is hypothesized that studying the immune environment of mixed tumors and responses to radiotherapy could nominate immune active therapies to enhance immune responses after radiotherapy.

Experimental design

Evaluate efficacy and immune responses generated by radiotherapy in tumors with different proportions of immunologically responsive and unresponsive tumor cells. Then study the cellular responses and transcriptomic differences between the tumors to nominate immunotherapy combinations with radiotherapy and evaluate the combination.

Results

The

SUBMITTER: Aguilera TA 

PROVIDER: S-EPMC7311370 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature