Based on Histogram Analysis: ADC_aqp Derived from Ultra-high b-Value DWI could be a Non-invasive Specific Biomarker for Rectal Cancer Prognosis.

ABSTRACT: Aquaporins (AQP) are not only water channel protein, but also potential prognostic indicator and therapeutic target for rectal cancer. Some previous studies have demonstrated the AQP expression could be estimated by ADC_aqp value derived from ultra-high b-value diffusion-weighted imaging (DWI). We aim to determine whether ADC_aqp could be a new and specific biomarker for indicating the AQP expression and prognostic factors of rectal cancer. 76 untreated patients with rectal cancer confirmed by colonoscopy biopsy were enrolled. ADC_aqp value was generated from ultra-high b-value DWI with five b-values (1700-3500 s/mm²). AQP (AQP1, 3 and 5)staining intensity was estimated by both of software (QuPath) and manual manner. The relationships between histog

SUBMITTER: Zhang G 

PROVIDER: S-EPMC7311405 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature