Comparison of differential accessibility analysis strategies for ATAC-seq data.

ABSTRACT: ATAC-seq is widely used to measure chromatin accessibility and identify open chromatin regions (OCRs). OCRs usually indicate active regulatory elements in the genome and are directly associated with the gene regulatory network. The identification of differential accessibility regions (DARs) between different biological conditions is critical in determining the differential activity of regulatory elements. Differential analysis of ATAC-seq shares many similarities with differential expression analysis of RNA-seq data. However, the distribution of ATAC-seq signal intensity is different from that of RNA-seq data, and higher sensitivity is required for DARs identification. Many different tools can be used to perform differential analysis of ATAC-seq data, but a comprehensive comparison and ben

SUBMITTER: Gontarz P 

PROVIDER: S-EPMC7311460 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature