The characteristic of the synonymous codon usage and phylogenetic analysis of hepatitis B virus.

ABSTRACT:

Background

Hepatitis B virus (HBV) infection is a crucial medical issue worldwide. The dependence of HBV replication on host cell machineries and their co-evolutionary interactions prompt the codon usage pattern of viral genes to translation selection and mutation pressure.

Objective

The evolutionary characteristics of HBV and the natural selection effects of the human genome on the codon usage characteristics were analyzed to provide a basis for medication development for HBV infection.

Methods

The codon usage pattern of sequences from different HBV genotypes of our isolates and reference HBV genome sequences downloaded from the National Center for Biotechnology Information (NCBI) database were analyzed by computing the relative synonymous codon usage (RSCU), nucleot

SUBMITTER: Qi X 

PROVIDER: S-EPMC7311504 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature