Eomes Expression Defines Group 1 Innate Lymphoid Cells During Metastasis in Human and Mouse.

ABSTRACT: Recent studies have attempted to uncover the role of Group 1 Innate lymphoid cells (ILCs) in multiple physiological contexts, including cancer. However, the definition and precise contribution of Group 1 ILCs (constituting ILC1 and NK subsets) to metastasis is unclear due to the lack of well-defined cell markers. Here, we first identified ILC1 and NK cells in NSCLC patient blood and differentiated them based on the expression of transcription factors, T-bet and Eomes. Interestingly, Eomes downregulation in the peripheral blood NK cells of NSCLC patients positively correlated with disease progression. Additionally, we noted higher Eomes expression in NK cells (T-bet⁺Eomes^hi) compared to ILC1s (T-bet⁺Eomes^lo). We asked whether the decrease in Eomes

SUBMITTER: Verma R 

PROVIDER: S-EPMC7311635 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature