Olfactory testing does not predict β-amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort.

ABSTRACT:

Objective

To explore the value of olfactory identification deficits as a predictor of cerebral β-amyloid status and other markers of brain health in cognitively normal adults aged ~ 70 years.

Methods

Cross-sectional observational cohort study. 389 largely healthy and cognitively normal older adults were recruited from the MRC National Survey of Health and Development (1946 British Birth cohort) and investigated for olfactory identification deficits, as measured by the University of Pennsylvania Smell Identification Test. Outcome measures were imaging markers of brain health derived from 3 T MRI scanning (cortical thickness, entorhinal cortex thickness, white matter hyperintensity volumes); ¹⁸F florbetapir amyloid-PET scanning; and cognitive testing results. Partic

SUBMITTER: Buchanan SM 

PROVIDER: S-EPMC7311798 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature