GABA_A Receptor/STEP61 Signaling Pathway May Be Involved in Emulsified Isoflurane Anesthesia in Rats.

ABSTRACT: (1) Background: Emulsified isoflurane (EISO) is a type of intravenous anesthetic. How emulsified isoflurane works in the brain is still unclear. The aim of this study was to explore whether epigenetic mechanisms affect anesthesia and to evaluate the anesthetic effects of emulsified isoflurane in rats. (2) Methods: Rats were randomly divided into four groups (n = 8/group): The tail vein was injected with normal saline 0.1 mL·kg^-1·min^-1for the control (Con) group, with intralipid for the fat emulsion (FE) group, with EISO at 60 mg·kg^-1·min^-1 for the high-concentration (HD) group, and 45 mg·kg^-1·min^-1 for the low-concentration (LD) group. The consciousness state, motor function of limbs, and response to nociceptive stimu

SUBMITTER: Zhao X 

PROVIDER: S-EPMC7312199 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature