Skeletal Muscle Gene Expression in Long-Term Endurance and Resistance Trained Elderly.

ABSTRACT: Physical exercise is deemed the most efficient way of counteracting the age-related decline of skeletal muscle. Here we report a transcriptional study by next-generation sequencing of vastus lateralis biopsies from elderly with a life-long high-level training practice (n = 9) and from age-matched sedentary subjects (n = 5). Unsupervised mixture distribution analysis was able to correctly categorize trained and untrained subjects, whereas it failed to discriminate between individuals who underwent a prevalent endurance (n = 5) or a prevalent resistance (n = 4) training, thus showing that the training mode was not relevant for sarcopenia prevention. KEGG analysis of transcripts showed that physical exercise affected a high number of metabolic and signaling pathways, in particular those relat

SUBMITTER: Bolotta A 

PROVIDER: S-EPMC7312229 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature