Critical role of OX40 in drug-induced acute liver injury.

ABSTRACT:

Background and purpose

The innate and adaptive immune systems both play important roles in drug-induced liver injury (DILI). However, the crosstalk between the innate and adaptive immunity in DILI is largely unknown. Extensive crosstalk is likely mandated by co-stimulatory interactions between these immune systems. OX40 is a co-stimulatory molecule, but whether it regulates the intrahepatic immune response in DILI remains unknown.

Experimental approach

Acute liver injury was induced by paracetamol (acetaminophen), carbon tetrachloride (CCl₄ ), and d-galactosamine/LPS (GalN/LPS) in wild-type (WT) and Ox40 knockout (KO) mice, and disease progress was compared.

Key results

Plasma OX40 levels were significantly increased and were augmented in intrahepatic CD4

SUBMITTER: Zhang C 

PROVIDER: S-EPMC7312313 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature