Differential hepatoprotective role of the cannabinoid CB₁ and CB₂ receptors in paracetamol-induced liver injury.

ABSTRACT:

Background and purpose

Protective mechanisms of the endogenous cannabinoid system against drug-induced liver injury (DILI) are actively being investigated regarding the differential regulatory role of the cannabinoid CB₁ and CB₂ receptors in liver fibrogenesis and inflammation.

Experimental approach

The 2-arachidonoylglycerol (2-AG)-related signalling receptors and enzymatic machinery, and inflammatory/fibrogenic factors were investigated in the liver of a mouse model of hepatotoxicity induced by acute and repeated overdoses (750 mg·kg^-1 ·day^-1 ) of paracetamol (acetaminophen), previously treated with selective CB₁ (ACEA) and CB₂ (JWH015) agonists (10 mg·kg^-1 ), or lacking CB₁ and CB

SUBMITTER: Rivera P 

PROVIDER: S-EPMC7312315 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature