Neuroprotection induced by dexpramipexole delays disease progression in a mouse model of progressive multiple sclerosis.

ABSTRACT:

Background and purpose

Drugs able to counteract progressive multiple sclerosis (MS) represent a largely unmet therapeutic need. Even though the pathogenesis of disease evolution is still obscure, accumulating evidence indicates that mitochondrial dysfunction plays a causative role in neurodegeneration and axonopathy in progressive MS patients. Here, we investigated the effects of dexpramipexole, a compound with a good safety profile in humans and able to sustain mitochondria functioning and energy production, in a mouse model of progressive MS.

Experimental approach

Female non-obese diabetic mice were immunized with MOG_35-55 . Functional, immune and neuropathological parameters were analysed during disease evolution in animals treated or not with dexpramipexole. T

SUBMITTER: Buonvicino D 

PROVIDER: S-EPMC7312322 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature