Riboflavin Deficiency-Implications for General Human Health and Inborn Errors of Metabolism.

ABSTRACT: As an essential vitamin, the role of riboflavin in human diet and health is increasingly being highlighted. Insufficient dietary intake of riboflavin is often reported in nutritional surveys and population studies, even in non-developing countries with abundant sources of riboflavin-rich dietary products. A latent subclinical riboflavin deficiency can result in a significant clinical phenotype when combined with inborn genetic disturbances or environmental and physiological factors like infections, exercise, diet, aging and pregnancy. Riboflavin, and more importantly its derivatives, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), play a crucial role in essential cellular processes including mitochondrial energy metabolism, stress responses, vitamin and cofactor biogenes

SUBMITTER: Mosegaard S 

PROVIDER: S-EPMC7312377 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature