Innovative Precision Gene-Editing Tools in Personalized Cancer Medicine.

ABSTRACT: The development of clustered regularly interspaced short palindromic repeats (CRISPR) has spurred a successive wave of genome-engineering following zinc finger nucleases and transcription activator-like effector nucleases, and made gene-editing a promising strategy in the prevention and treatment of genetic diseases. However, gene-editing is not widely adopted in clinics due to some technical issues that challenge its safety and efficacy, and the lack of appropriate clinical regulations allowing them to advance toward improved human health without impinging on human ethics. By systematically examining the oncological applications of gene-editing tools and critical factors challenging their medical translation, genome-editing has substantial contributions to cancer driver gene discovery, tu

SUBMITTER: Dai X 

PROVIDER: S-EPMC7312441 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature