Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy.

ABSTRACT: Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting in elevated cost for public health systems. DN is the main cause of chronic kidney disease (CKD) and its incidence increases the number of patients that develop the end-stage renal disease (ESRD). There are growing epidemiological and preclinical evidence about the close relationship between inflammatory response and the occurrence and progression of DN. Several anti-inflammatory strategies targeting specific inflammatory mediators (cell adhesion molecules, chemokines and cytokines) and intracellular signaling pathways have shown beneficial effects in experimental models of DN, decreasing proteinuria and renal lesions. A number of inflammatory molecules have been shown useful to identify diabetic p

SUBMITTER: Rayego-Mateos S 

PROVIDER: S-EPMC7312633 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature