Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical Implications.

ABSTRACT: Dendritic cells (DCs) constitute a complex network of cell subsets with common functions but also with many divergent aspects. All dendritic cell subsets share the ability to prime T cell response and to undergo a complex trafficking program related to their stage of maturation and function. For these reasons, dendritic cells are implicated in a large variety of both protective and detrimental immune responses, including a crucial role in promoting anti-tumor responses. Although cDC1s are the most potent subset in tumor antigen cross-presentation, they are not sufficient to induce full-strength anti-tumor cytotoxic T cell response and need close interaction and cooperativity with the other dendritic cell subsets, namely cDC2s and pDCs. This review will take into consideration different asp

SUBMITTER: Del Prete A 

PROVIDER: S-EPMC7312661 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature