Expression of MicroRNAs in Periodontal and Peri-Implant Diseases: A Systematic Review and Meta-Analysis.

ABSTRACT:

Aim

The purpose of this review was to evaluate the expression patterns of miRNAs in periodontal and peri-implant diseases, while identifying potential miRNAs with the greatest diagnostic ability as an oral fluid biomarker.

Materials and methods

Human and animal studies were included when evaluating expression of miRNAs between health and different forms/stages of diseases, in which microarray and/or real-time polymerase chain reaction (RT-PCR) was carried out to detect fold changes in gene expression. After full-text analysis, 43 articles were considered for a qualitative assessment, and 16 miRNAs were selected to perform meta-analysis.

Results

Based on human studies, results showed an overall upregulation of most of the evaluated miRNAs in periodontitis, with miRNA-1

SUBMITTER: Asa'ad F 

PROVIDER: S-EPMC7312949 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature