Three years of growth hormone treatment in young adults with Prader-Willi syndrome: sustained positive effects on body composition.

ABSTRACT:

Background

In children with Prader-Willi syndrome (PWS), the benefits of growth hormone treatment are well established. Several one-year studies have shown that growth hormone is also beneficial for adults with PWS, improving body composition. However, little is known about the longer-term effects. This study investigated the effects on body composition in adult patients with PWS during 3 years of growth hormone therapy in a dose of 0.33 mg/m²/day.

Methods

Open-label, prospective study in 43 young adults with PWS with a median (IQR) age of 19.0 (17.5 to 20.7) years. Fat mass percentage SDS and lean body mass SDS were measured annually by DXA.

Results

Estimated mean (95% CI) fat mass percentage SDS decreased during the three-year study from 2.1 (1.9 to 2.3)

SUBMITTER: Damen L 

PROVIDER: S-EPMC7313113 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature