Evaluating blood-brain barrier permeability in a rat model of type 2 diabetes.

ABSTRACT:

Background

This is an exploratory study using a novel imaging modality, quantitative ultrashort time-to-echo, contrast enhanced (QUTE-CE) magnetic resonance imaging to evaluate the permeability of the blood-brain barrier in a rat model of type 2 diabetes with the presumption that small vessel disease is a contributing factor to neuropathology in diabetes.

Methods

The BBZDR/Wor rat, a model of type 2 diabetes, and age-matched controls were studied for changes in blood-brain barrier permeability. QUTE-CE, a quantitative vascular biomarker, generated angiographic images with over 500,000 voxels that were registered to a 3D MRI rat brain atlas providing site-specific information on blood-brain barrier permeability in 173 different brain areas.

Results

In this model of dia

SUBMITTER: Qiao J 

PROVIDER: S-EPMC7313122 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature