Ex vivo modelling of drug efficacy in a rare metastatic urachal carcinoma.

ABSTRACT:

Background

Ex vivo drug screening refers to the out-of-body assessment of drug efficacy in patient derived vital tumor cells. The purpose of these methods is to enable functional testing of patient specific efficacy of anti-cancer therapeutics and personalized treatment strategies. Such approaches could prove powerful especially in context of rare cancers for which demonstration of novel therapies is difficult due to the low numbers of patients. Here, we report comparison of different ex vivo drug screening methods in a metastatic urachal adenocarcinoma, a rare and aggressive non-urothelial bladder malignancy that arises from the remnant embryologic urachus in adults.

Methods

To compare the feasibility and results obtained with alternative ex vivo drug screening techniques,

SUBMITTER: Makela R 

PROVIDER: S-EPMC7313172 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature