Post-developmental extracellular proteoglycan maintenance in attractin-deficient mice.

ABSTRACT:

Objective

Neurodegeneration and hair pigmentation alterations in mice occur consequent to aberrations at the Atrn locus coding for the transmembrane form of attractin. Earlier results pointed to a possible involvement in intracellular trafficking/export of secretory vesicles containing proteoglycan. Here we examined kidney and liver, both heavily dependent upon proteoglycan, of attractin-deficient mice to determine whether abnormalities were observed in these tissues.

Results

Histological and histochemical analysis to detect glycosylated protein identified a severe loss in attractin-deficient mice of extracellular proteoglycan between kidney tubules in addition to a loss of glycosylated material within the intratubular brush border. In the liver, extracellular matrix materia

SUBMITTER: Azouz A 

PROVIDER: S-EPMC7313179 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature