Homogeneous and Narrow Bandwidth of Spike Initiation in Rat L1 Cortical Interneurons.

ABSTRACT: The cortical layer 1 (L1) contains a population of GABAergic interneurons, considered a key component of information integration, processing, and relaying in neocortical networks. In fact, L1 interneurons combine top-down information with feed-forward sensory inputs in layer 2/3 and 5 pyramidal cells (PCs), while filtering their incoming signals. Despite the importance of L1 for network emerging phenomena, little is known on the dynamics of the spike initiation and the encoding properties of its neurons. Using acute brain tissue slices from the rat neocortex, combined with the analysis of an existing database of model neurons, we investigated the dynamical transfer properties of these cells by sampling an entire population of known "electrical classes" and comparing experiments and model p

SUBMITTER: Borda Bossana S 

PROVIDER: S-EPMC7313227 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature