Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†.

ABSTRACT: Successful assisted reproductive technology pregnancy depends on the viability of embryos and endometrial receptivity. However, the literature has neglected effects of the endometrial environment during the proliferative phase on implantation success or failure. Human endometrial stromal cells (hESCs) were isolated from endometrial tissues sampled at oocyte retrieval during the proliferative phase from women undergoing infertility treatment. Primary hESC cultures were used to investigate the relationship between stemness and senescence induction in this population and embryo receptivity. Patients were classified as receptive or non-receptive based on their pregnancy diagnosis after embryo transfer. Biomarkers of cellular senescence and somatic stem cells were compared between each sample.

SUBMITTER: Tomari H 

PROVIDER: S-EPMC7313258 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature