Incidence and predictors of early seizures in intracerebral haemorrhage and the effect of tranexamic acid.

ABSTRACT:

Introduction

Seizures are common after intracerebral haemorrhage. Tranexamic acid increases the risk of seizures in non-intracerebral haemorrhage population but its effect on post-intracerebral haemorrhage seizures is unknown. We explored the risk factors and outcomes of seizures after intracerebral haemorrhage and if tranexamic acid increased the risk of seizures in the Tranexamic acid for IntraCerebral Haemorrhage-2 trial.

Patients and methods

Seizures were reported prospectively up to day 90. Cox regression analyses were used to determine the predictors of seizures within 90 days and early seizures (≤7 days). We explored the effect of early seizures on day 90 outcomes.

Results

Of 2325 patients recruited, 193 (8.3%) had seizures including 163 (84.5%) early seizures

SUBMITTER: Law ZK 

PROVIDER: S-EPMC7313371 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature