Somatic mutations of triple-negative breast cancer: a comparison between Black and White women.

ABSTRACT:

Purpose

Understanding the contribution of tumor genome biology to racial disparities of triple-negative breast cancer (TNBC) is important for narrowing the cancer mortality gap between Black and White women.

Methods

We evaluated tumor somatic mutations using targeted sequencing of a customized panel of 151 genes and 15 copy number variations (CNVs) within a population of 133 TNBC patients, including 71 Black and 62 White women.

Results

The overall mutational burden between Black and White women with TNBC was not significantly different, with a median of 5 somatic changes per patient (point mutations and CNVs combined) for the customized panel (range 1-31 for Blacks vs. 1-26 for Whites; p = 0.76). Of the 151 genes examined, none were mutated at a significantly higher f

SUBMITTER: Omilian AR 

PROVIDER: S-EPMC7313393 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature